Pexmetinib (Standard)
Pexmetinib (Standard) is the analytical standard of Pexmetinib. This product is intended for research and analytical applications. Pexmetinib is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia.
Product Specifications
CAS Number
945614-12-0
UNSPSC
12352100
Target
Autophagy; p38 MAPK; Reference Standards; Tie
Related Pathways
Autophagy; MAPK/ERK Pathway; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5
Molecular Formula
C31H33FN6O3
Molecular Weight
556.63
References & Citations
[1]Bachegowda L, et al. Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia. Cancer Res. 2016 Aug 15;76 (16) :4841-4849.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
041609 200 µL
SF1, ID (SF1, ZFM1, ZNF162, Splicing factor 1, Mammalian branch point-binding protein, Transcription factor ZFM1, Zinc finger gene in MEN1 locus, Zinc finger protein 162)
Sign In for Pricing
View Details A52820-50UG 50 µg
Intermediate capsid protein VP6 Antibody, Biotin conjugated
Sign In for Pricing
View Details MBS1088431 Inquire
Recombinant Bertholletia excelsa 2S sulfur-rich seed storage protein 2 (BE2S2), partial
Sign In for Pricing
View Details abx305470-01 20 µg
Sulfotransferase Family 1B Member 1 (SULT1B1) Antibody (FITC)
Sign In for Pricing
View Details abx305470-02 50 µg
Sulfotransferase Family 1B Member 1 (SULT1B1) Antibody (FITC)
Sign In for Pricing
View Details