SOS1 activator 2
SOS1 activator 2 (Compound 65) is a benzimidazole derivative and a SOS1 activator. SOS1 activator 2 has a high binding affinity for SOS1 with a Kd of 9 nM. SOS1 activator 2 can regulate the Ras-ERK signaling pathway, which can be used in the study of cancer[1].
Product Specifications
CAS Number
2245237-54-9
UNSPSC
12352005
Target
ERK; Ras; SOS1
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
FC1=C(C)C=C(CN2C3=C(N=C2N4CC5(C4)CNC5)C(C6=C(C)NN=C6C)=CC(Cl)=C3)C=C1C
Molecular Formula
C26H28ClFN6
Molecular Weight
478.99
References & Citations
[1]Hodges TR, et al. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61 (19) :8875-8894.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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