Resolvin D5 n-3 DPA

Resolvin D5 n-3 DPA is a Docosapentaenoic acid (DPA) derived specialized proresolving lipid mediator (SPM) . Resolvin D5 n-3 DPA is a GPR101, GPR12, and GPR84 agonist with EC50s of 4.6 pM, 14 pM, and 1.5 pM, respectively. Resolvin D5 n-3 DPA possesses potent pro-resolution and anti-inflammatory actions. Resolvin D5 n-3 DPA reduces cell adhesion onto TNF-α-activated human endothelial monolayers. Resolvin D5 n-3 DPA displays potent leukocyte-directed activities, upregulating the ability of neutrophils and macrophages to phagocytose bacteria. Resolvin D5 n-3 DPA can be used for the study of intestinal inflammation[1][2][3].

Product Specifications

CAS Number

[1609382-32-2]

UNSPSC

12352211

Target

GPR84

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology

Smiles

[C@@H](/C=C/C=C\C/C=C\C=C\[C@H](C/C=C\CC)O)(CCCCCC(O)=O)O

Molecular Formula

C22H34O4

Molecular Weight

362.51

References & Citations

[1]Correction for Gobbetti et al., Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. Proc Natl Acad Sci U S A. 2024 Feb 27;121 (9) :e2322427121. |[2]Ervik K, et al. Stereoselective Synthesis, Pro-resolution, and Anti-inflammatory Actions of RvD5n-3 DPA. J Nat Prod. 2023 Nov 24;86 (11) :2546-2553. |[3]Flak MB, et al. GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections. J Clin Invest. 2020 Jan 2;130 (1) :359-373.