Vericiguat-d6

Vericiguat-d6 (BAY1021189-d6) is deuterium labeled Vericiguat. Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.

Product Specifications

Product Name Alternative

BAY1021189-d6

UNSPSC

12352005

Target

Guanylate Cyclase; Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Others

Applications

Cancer-programmed cell death

Field of Research

Cardiovascular Disease; Cancer

Smiles

O=C(OC)NC1=C(N)N=C(C2=NN(C([2H])([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C3F)C4=NC=C(F)C=C42)N=C1N

Molecular Formula

C19H10D6F2N8O2

Molecular Weight

432.42

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Follmann M, et al. Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure. J Med Chem. 2017 Jun 22;60 (12) :5146-5161.