(Z) -Rilpivirine

(Z) -Rilpivirine ((Z) -R278474) is the (Z) -isomer of Rilpivirine (HY-10574) . Rilpivirine is an effective and selective diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI) . It exhibits potent antiviral activity against both wild-type HIV (EC50 = 0.4 nM) and mutant strains (EC50 = 0.1-2.0 nM) [1].

Product Specifications

CAS Number

[500287-94-5]

Product Name Alternative

(Z) -R278474; (Z) -TMC278; (Z) -DB08864

UNSPSC

12352005

Target

Drug Isomer; HIV; Reverse Transcriptase

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

CC(C=C(C=C1C)/C=C\C#N)=C1NC2=NC(NC3=CC=C(C=C3)C#N)=NC=C2

Molecular Formula

C22H18N6

Molecular Weight

366.42

References & Citations

[1]Reilly SW, et al. Late-Stage Carbon Isotope Exchange of Aryl Nitriles through Ni-Catalyzed C-CN Bond Activation. J Am Chem Soc. 2021 Mar 31;143 (12) :4817-4823.