Oxomemazine (hydrochloride)

Oxomemazine hydrochloride is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine hydrochloride is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki= 84 nM, M1 receptor) and low (Ki= 1.65 μM, M2 receptor) affinity sites[1]. Oxomemazine hydrochloride an antihistamine and anticholinergic agent used for the study of cough treatment[2].

Product Specifications

CAS Number

[4784-40-1]

UNSPSC

12352005

Target

Histamine Receptor; mGluR

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=S1(C2=C(N(CC(CN(C)C)C)C3=C1C=CC=C3)C=CC=C2)=O.Cl

Molecular Formula

C18H23ClN2O2S

Molecular Weight

366.91

References & Citations

[1] S W Lee, et al.Selectivity of oxomemazine for the M1 muscarinic receptors.Arch Pharm Res. 1994 Dec;17 (6) :443-51.|[2] M S Siddegowda, et al.Oxomemazine hydro-chloride. Acta Crystallogr Sect E Struct Rep Online. 2011 Aug 1;67 (Pt 8) :o1875.