Ketoprofen (sodium)

Ketoprofen (RP-19583) sodium is a non-steroidal anti-inflammatory agent. Ketoprofen sodium can inhibit the activity of Cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2) . Ketoprofen is potential in the research of inflammation, immunology, and metabolic disease such as obesity[1][2][3].

Product Specifications

CAS Number

[57495-14-4]

Product Name Alternative

19583 RP-Na

UNSPSC

12352005

Target

COX

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Smiles

O=C(C(C)C1=CC(C(C2=CC=CC=C2)=O)=CC=C1)O[Na]

Molecular Formula

C16H13NaO3

Molecular Weight

276.26

References & Citations

[1]Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12 (4) :533-7.|[2]NamHyeon Kang Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. Pflugers Arch. 2020 May;472 (5) :583-596.|[3]Denisa Dan, et al. Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro. J Dairy Sci. 2018 Dec;101 (12) :11321-11329.