Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Pexidartinib (Standard)

Pexidartinib (Standard) is the analytical standard of Pexidartinib. This product is intended for research and analytical applications. Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity[1].

Product Specifications

CAS Number

1029044-16-3

UNSPSC

12352100

Target

Apoptosis; c-Fms; c-Kit; Reference Standards

Related Pathways

Apoptosis; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F

Molecular Formula

C20H15ClF3N5

Molecular Weight

417.81

References & Citations

[1]DeNardo DG, et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 2011 Jun;1 (1) :54-67.|[2]Kuse Y, et al. Microglia increases the proliferation of retinal precursor cells during postnatal development. Mol Vis. 2018 Jul 30;24:536-545. eCollection 2018.|[3]Lee JH, et al. A phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors. Invest New Drugs. 2019 Mar 2.|[4]Merry TL, et al. The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice. Int J Obes (Lond) . 2020;44 (1) :245-253.|[5]Luo L, et al. Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice. J Neuroinflammation. 2022 Jun 11;19 (1) :141.|[6]Chadarevian JP, et al. Engineering an inhibitor-resistant human CSF1R variant for microglia replacement. J Exp Med. 2023 Mar 6;220 (3) :e20220857.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Hepatitis A Virus Surface Antigen (HAsAg, HAV) (AP)
MBS6247969-01 0.1 mL

Hepatitis A Virus Surface Antigen (HAsAg, HAV) (AP)

Sign In for Pricing
View Details
Hepatitis A Virus Surface Antigen (HAsAg, HAV) (AP)
MBS6247969-02 5x 0.1 mL

Hepatitis A Virus Surface Antigen (HAsAg, HAV) (AP)

Sign In for Pricing
View Details
FRA14B Protein Vector (Human) (pPM-C-HA)
PV078983 500 ng

FRA14B Protein Vector (Human) (pPM-C-HA)

Sign In for Pricing
View Details
Prostacyclin ELISA Kit
E4767-100 100 Assays

Prostacyclin ELISA Kit

Sign In for Pricing
View Details
GCLM Antibody, Biotin conjugated
A22921-100UG 100 µg

GCLM Antibody, Biotin conjugated

Sign In for Pricing
View Details
Bovine Olfactory receptor 52E1 (OR52E1P) ELISA Kit
GTR10352405 96 Well

Bovine Olfactory receptor 52E1 (OR52E1P) ELISA Kit

Sign In for Pricing
View Details