Eleclazine (hydrochloride) (Standard)
Eleclazine (hydrochloride) (Standard) is the analytical standard of Eleclazine (hydrochloride) . This product is intended for research and analytical applications. Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 value of [1][2][3].
Product Specifications
CAS Number
1448754-43-5
UNSPSC
12352100
Target
Potassium Channel; Reference Standards; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cardiovascular Disease
Smiles
O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13.[H]Cl
Molecular Formula
C21H17ClF3N3O3
Molecular Weight
451.83
References & Citations
[1]Rajamani S et al. The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations. Br J Pharmacol. 2016 Jul 23.|[2]Bacic D, et al. Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model. Heart Rhythm. 2017 Mar;14 (3) :448-454.|[3]Potet F, Egecioglu DE, Burridge PW, George AL Jr. GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Mol Pharmacol. 2020 Nov;98 (5) :540-547.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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