SR-302

SR-302, a chemical probe, is a potent and selectivity DDR/p38 inhibitor, with IC50 values of 0.125, 0.023 and 0.018 μM for p38α, DDR1 and DDR2, respectively. SR-302 can be used for the research of fibrotic disorders, such as renal and pulmonary fibrosis, atherosclerosis, and various forms of cancer[1].

Product Specifications

CAS Number

[2771319-74-3]

UNSPSC

12352005

Target

Discoidin Domain Receptor; p38 MAPK

Related Pathways

MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Purity

98.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CS(N(CCC1)CC1NC([C@H](CCC2CCCCC2)NC(C(C=C3)=CC=C3CNC(C4=CN=C5N4C=CC=C5)=O)=O)=O)(=O)=O

Molecular Formula

C32H42N6O5S

Molecular Weight

622.78

References & Citations

[1]Röhm S, et al. Development of a Selective Dual Discoidin Domain Receptor (DDR) /p38 Kinase Chemical Probe. J Med Chem. 2021 Sep 23;64 (18) :13451-13474.