(Rac) -Aurora A/PKC-IN-1
(Rac) -Aurora A/PKC-IN-1 (Compund 2e) is an orally active Aurora A and PKC (α, β1, β2 and θ) kinase inhibitor. (Rac) -Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells in vitro and antimetastatic activity in vivo[1].
Product Specifications
CAS Number
2143100-98-3
UNSPSC
12352005
Target
Aurora Kinase; PKC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; TGF-beta/Smad
Field of Research
Cancer
Smiles
O=C1C2=C([Se]N1C3=NC4=C(C(NC5C[Se]CC5)=N3)NC=N4)C=CC=C2
Molecular Formula
C16H14N6OSe2
Molecular Weight
464.24
References & Citations
[1]Bijian K, et al. Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity. J Med Chem. 2022 Feb 24;65 (4) :3134-3150.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; PKCα; PKCβ; PKCθ
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