AY 31906
AY 31906 is an orally active pyrimidine sulfonamide diuretic. AY 31906 exhibits potent diuretic and natriuretic activities in rats and dogs, along with relatively potassium-sparing properties. AY 31906 exhibits superior activity to Furosemide. AY-31906 also has antihypertensive effects and can be used in the research of cardiovascular diseases[1][2].
Product Specifications
CAS Number
124788-46-1
UNSPSC
12352005
Target
NKCC; Potassium Channel; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
CC(C)NC(NS(=O)(C1=CN=C(N)N=C1N[C@H]2[C@@]3([H])C[C@@](CC3)([H])C2)=O)=O
Molecular Formula
C15H24N6O3S
Molecular Weight
368.45
References & Citations
[1]Ackerman DM, et al. AY-31,906, a novel high ceiling diuretic: characterization of its relative potassium-sparing actions in rats and dogs. J Pharmacol Exp Ther. 1989 Dec;251 (3) :1113-9.|[2]Lang H J, et al. Discovery and development of diuretic agents. Diuretics, 1995: 141-172.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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