AY 31906

AY 31906 is an orally active pyrimidine sulfonamide diuretic. AY 31906 exhibits potent diuretic and natriuretic activities in rats and dogs, along with relatively potassium-sparing properties. AY 31906 exhibits superior activity to Furosemide (HY-B0135) . AY-31906 also has antihypertensive effects and can be used in the research of cardiovascular diseases[1][2].

Product Specifications

CAS Number

[124788-46-1]

UNSPSC

12352005

Target

NKCC; Potassium Channel; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

CC(C)NC(NS(=O)(C1=CN=C(N)N=C1N[C@H]2[C@@]3([H])C[C@@](CC3)([H])C2)=O)=O

Molecular Formula

C15H24N6O3S

Molecular Weight

368.45

References & Citations

[1]Ackerman DM, et al. AY-31,906, a novel high ceiling diuretic: characterization of its relative potassium-sparing actions in rats and dogs. J Pharmacol Exp Ther. 1989 Dec;251 (3) :1113-9.|[2]Lang H J, et al. Discovery and development of diuretic agents. Diuretics, 1995: 141-172.