ISO-1 (Standard)
ISO-1 (Standard) is the analytical standard of ISO-1. This product is intended for research and analytical applications. ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
Product Specifications
CAS Number
478336-92-4
UNSPSC
12352100
Target
Macrophage migration inhibitory factor (MIF) ; Reference Standards
Related Pathways
Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology
Smiles
O=C(OC)CC1ON=C(C(C=C2)=CC=C2O)C1
Molecular Formula
C12H13NO4
Molecular Weight
235.24
References & Citations
[1]Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277 (28) :24976-82.|[2]Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280 (44) :36541-4.|[3]Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3 (3) :135-142.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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