ISO-1 (Standard)

ISO-1 (Standard) is the analytical standard of ISO-1. This product is intended for research and analytical applications. ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.

Product Specifications

CAS Number

[478336-92-4]

UNSPSC

12352100

Target

Macrophage migration inhibitory factor (MIF) ; Reference Standards

Related Pathways

Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology

Smiles

O=C(OC)CC1ON=C(C(C=C2)=CC=C2O)C1

Molecular Formula

C12H13NO4

Molecular Weight

235.24

References & Citations

[1]Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277 (28) :24976-82.|[2]Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280 (44) :36541-4.|[3]Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3 (3) :135-142.