Ketoconazole carbonyl-13C

Ketoconazole carbonyl-13C (Ketoconazol-13C) is 13C labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

Product Specifications

Product Name Alternative

Ketoconazol-13C; R 41400-13C

UNSPSC

12352005

Target

Bacterial; Cytochrome P450; Fungal; Isotope-Labeled Compounds; Ras

Related Pathways

Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Smiles

O=[13C](C)N(CC1)CCN1C(C=C2)=CC=C2OC[C@H](O3)CO[C@]3(CN4C=CN=C4)C5=C(Cl)C=C(Cl)C=C5

Molecular Formula

C25 13CH28Cl2N4O4

Molecular Weight

532.42

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51 (2) :165-75.|[3]Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24 (8) :367-70.|[4]Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151 (9) :4301-12.|[5]Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8 (1) :8161.