JAK1-IN-17

JAK1-IN-17 (Compound 31) is a highly selective inhibitor of JAK1 with a Ki of 1.9 nM. JAK1-IN-17 exhibits a low whole blood shift, which allows maintaining good whole blood potency. JAK1-IN-17 is also a nitrile-containing analogue with consistent, yet weak reversible inhibition of CYP3A4 using a midazolam probe (IC50 = 7.9 μM) . JAK1-IN-17 can be studied in cancer research[1].

Product Specifications

CAS Number

[1315490-71-1]

UNSPSC

12352005

Target

JAK

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

N#C[C@H]1CC[C@H](N2C([C@H](O)C)=NC3=CN=C(NC=C4)C4=C32)CC1

Molecular Formula

C17H19N5O

Molecular Weight

309.37

References & Citations

[1]Mark Zak, et al., Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2. J. Med. Chem. 2013, 56, 11, 4764–4785.