S 8849-1-d4 (free base)

S 8849-1-d4 (free base) (Tianeptine metabolite MC5-d4) is deuterium labeled S 8849-1 (free base) . S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants[1][2].

Product Specifications

CAS Number

[1330822-91-7]

Product Name Alternative

Tianeptine metabolite MC5-d4

UNSPSC

12352005

Target

Drug Metabolite; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

OC(CC([2H])([2H])C([2H])([2H])CNC1C2=CC=C(Cl)C=C2S(=O)(N(C3=CC=CC=C31)C)=O)=O

Molecular Formula

C19H17D4ClN2O4S

Molecular Weight

412.92

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Gaulier JM, et al. High-performance liquid chromatographic determination of tianeptine in plasma applied to pharmacokinetic studies. J Chromatogr B Biomed Sci Appl. 2000 Oct 10;748 (2) :407-14. |[3]Szafarz M, et al. Pharmacokinetic study of tianeptine and its active metabolite MC5 in rats following different routes of administration using a novel liquid chromatography tandem mass spectrometry analytical method. Naunyn Schmiedebergs Arch Pharmacol. 2018 Feb;391 (2) :185-196.