MI-888 (TFA)
MI-888 (TFA) is an orally active MDM2-p53 interaction inhibitor with a Ki of 0.44 nM. MI-888 (TFA) can achieve rapid, complete, and sustained tumor regression in a xenograft mouse model of cancer[1].
Product Specifications
CAS Number
1303609-30-4
UNSPSC
12352005
Target
MDM-2/p53
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C([C@H](N[C@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@@]31C(NC4=C3C=CC(Cl)=C4)=O)N[C@H]5C[C@](C)(O)C5.O=C(O)C(F)(F)F
Molecular Formula
C30H33Cl2F4N3O5
Molecular Weight
662.50
References & Citations
[1]Zhao Y, et al. A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. J Med Chem. 2013 Jul 11;56 (13) :5553-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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