Brefeldin A (Standard)

Brefeldin A (Standard) (BFA (Standard) ) is the analytical standard of Rutin. This product is intended for research and analytical applications. Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A inhibits HSV-1 and has anti-cancer activity.

Product Specifications

CAS Number

[20350-15-6]

Product Name Alternative

BFA (Standard) ; Cyanein (Standard) ; Decumbin (Standard)

UNSPSC

12352005

Target

Antibiotic; Autophagy; Bacterial; CRISPR/Cas9; HSV; Mitophagy; Reference Standards

Related Pathways

Anti-infection; Autophagy; Cell Cycle/DNA Damage; Others

Field of Research

Cancer; Infection

Smiles

O[C@@H]1C[C@]2([H])[C@@](/C=C/CCC[C@H](C)OC(/C=C/[C@H]2O)=O)([H])C1

Molecular Formula

C16H24O4

Molecular Weight

280.36

References & Citations

[1]Alvarez C, et al. Brefeldin A (BFA) disrupts the organization of the microtubule and the actin cytoskeletons. Eur J Cell Biol. 1999 Jan;78 (1) :1-14.|[2]Colanzi A, et al. Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Proc Natl Acad Sci U S A. 2013 Jun 11;110 (24) :9794-9.|[3]Tseng CN, et al. Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells. Molecules. 2014 Oct 29;19 (11) :17464-77.|[4]Wang J, et al. Erythroleukemia cells acquire an alternative mitophagy capability. Sci Rep. 2016 Apr 19;6:24641.|[5]Yu C, et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell. 2015 Feb 5;16 (2) :142-7.|[6]Nozawa N, et al. Subcellular localization of herpes simplex virus type 1 UL51 protein and role of palmitoylation in Golgi apparatus targeting. J Virol. 2003 Mar;77 (5) :3204-16.|[7]Jensen HL, Rygaard J, Norrild B. A time-related study of Brefeldin A effects in HSV-1 infected cultured human fibroblasts. APMIS. 1995;103 (7-8) :530-539. doi:10.1111/j.1699-0463.1995.tb01402.x