Sonidegib (Standard)
Sonidegib (Standard) is the analytical standard of Sonidegib. This product is intended for research and analytical applications. Sonidegib (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively[1].
Product Specifications
CAS Number
956697-53-3
UNSPSC
12352100
Target
Reference Standards; Smo
Related Pathways
Others; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C1=C(C)C(C(C=C2)=CC=C2OC(F)(F)F)=CC=C1)NC3=CC=C(N=C3)N4C[C@@H](C)O[C@@H](C)C4
Molecular Formula
C26H26F3N3O3
Molecular Weight
485.50
References & Citations
[1]Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1 (3) :130-4.|[2]Irvine DA, et al. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci Rep. 2016 May 9;6:25476.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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