Colchicine, suitable for plant cell culture

Colchicine, suitable for plant cell culture, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) . Colchicine prevents non-steroidal anti-inflammatory drug (NSAID) -induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine, suitable for plant cell culture can be used for plant cell culture[1][2][3][4][5].

Product Specifications

CAS Number

[64-86-8]

UNSPSC

12352200

Target

Biochemical Assay Reagents; Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Others

Field of Research

Cancer; Inflammation/Immunology

Smiles

CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)=O

Molecular Formula

C22H25NO6

Molecular Weight

399.44

References & Citations

[1]Bonfoco E, et al. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res. 1995 May;218 (1) :189-200.|[2]Hastie SB. Interactions of colchicine with tubulin. Pharmacol Ther. 1991;51 (3) :377-401. |[3]Yuanjun Tang, et al. Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury. Front Pharmacol. 2021 Dec 16:12:804030. |[4]Otani K, et al. Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Sci Rep. 2016 Sep 2;6:32587. |[5]Carola Muñoz-Montesino, et al. Inhibition of the Glycine Receptor alpha 3 Function by Colchicine. Front Pharmacol. 2020 Jul 30;11:1143. |[6]Lumkwana D, et al. Laminin, laminin-entactin and extracellular matrix are equally appropriate adhesive substrates for isolated adult rat cardiomyocyte culture and experimentation. Cell Adh Migr. 2018;12 (5) :503-511.