MCB-22-174

MCB-22-174 is a deuterated Piezo1 agonist, with an EC50 value of 6.28 μM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca2+ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP) [1].

Product Specifications

CAS Number

[3058199-58-6]

UNSPSC

12352005

Target

CaMK; ERK; Isotope-Labeled Compounds; Piezo Channel

Related Pathways

MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Others; Stem Cell/Wnt

Field of Research

Metabolic Disease

Purity

99.78

Smiles

ClC(C=CC=C1Cl)=C1C([2H])SC2=NN=C(C3=NC=C(NC[C@H](O)C)N=C3)S2

Molecular Formula

C16H14DCl2N5OS2

Molecular Weight

429.37

References & Citations

[1]Hao R, et al. A Novel Piezo1 Agonist Promoting Mesenchymal Stem Cell Proliferation and Osteogenesis to Attenuate Disuse Osteoporosis. Small Sci. 2024 Jun 30;4 (9) :2400061.