Trpvicin
Trpvicin is a potent and subtype-selective TRPV3 inhibitor with IC50s of 0.41 and 0.22 μM for hTRPV3-WT and hTRPV3-G573S mutant, respectively. Trpvicin exhibits minimal effects on other TRP family members (such as TRPV1/2/4/5/6, TRPA1 and TRPM8) . Trpvicin inhibits the TRPV3 channel by stabilizing it in a closed state via VSLD-PD binding. Trpvicin accesses additional binding sites inside the central cavity of the G573S mutant to remodel symmetry and block the channel. Trpvicin inhibits itch and hair loss in mouse models. Trpvicin can be used for study of inflammation and immunology[1].
Product Specifications
CAS Number
[2019994-90-0]
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.4
Smiles
N#CC(C)(C)C1=NC=CC(C2=C(C(F)(F)F)N=C(NC(C3=C(OC)N=CN=C3OC)=O)S2)=C1
Molecular Formula
C20H17F3N6O3S
Molecular Weight
478.45
References & Citations
[1]Fan J, et al. Structural basis of TRPV3 inhibition by an antagonist. Nat Chem Biol. 2023 Jan;19 (1) :81-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV3
Available Sizes
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