Opc 14117

OPC-14117 is an orally active superoxide radical scavenger that can cross the blood-brain barrier. OPC-14117 inhibits the oxidative stress cascade reaction, significantly reducing the increase in tissue osmotic pressure and alleviating brain edema in the brain contusion model. OPC-14117 blocks the NF-κB-dependent apoptotic pathway in the striatum neuron apoptosis model induced by Quinolinic acid (HY-100807) . OPC-14117 can reduce the necrotic volume, protect hippocampal CA3 neurons and restore cognitive function. OPC-14117 can be used to study secondary brain injury and improve neurological prognosis[1][2].

Product Specifications

CAS Number

[103233-65-4]

UNSPSC

12352005

Target

Apoptosis; NF-κB; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

OC1=C2C(CC(C)(C2NC(CN3CCN(CC3)C4=CC(OC)=CC=C4)=O)C)=C(C=C1C)C

Molecular Formula

C26H35N3O3

Molecular Weight

437.57

References & Citations

[1]Nakai M, et al. Free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF-kappaB activation and apoptosis in rat striatum. Brain Res Mol Brain Res. 1999 Jan 22;64 (1) :59-68.|[2]Aoyama N, et al. Effects of antioxidant, OPC-14117, on secondary cellular damage and behavioral deficits following cortical contusion in the rat. Brain Res. 2002 May 3;934 (2) :117-24.