Opc 14117
OPC-14117 is an orally active superoxide radical scavenger that can cross the blood-brain barrier. OPC-14117 inhibits the oxidative stress cascade reaction, significantly reducing the increase in tissue osmotic pressure and alleviating brain edema in the brain contusion model. OPC-14117 blocks the NF-κB-dependent apoptotic pathway in the striatum neuron apoptosis model induced by Quinolinic acid. OPC-14117 can reduce the necrotic volume, protect hippocampal CA3 neurons and restore cognitive function. OPC-14117 can be used to study secondary brain injury and improve neurological prognosis[1][2].
Product Specifications
CAS Number
103233-65-4
UNSPSC
12352005
Target
Apoptosis; NF-κB; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
OC1=C2C(CC(C)(C2NC(CN3CCN(CC3)C4=CC(OC)=CC=C4)=O)C)=C(C=C1C)C
Molecular Formula
C26H35N3O3
Molecular Weight
437.57
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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