TDPAM01
TDPAM01 is a positive allosteric modulator of AMPA receptor GluA2. TDPAM01 can specifically bind to the ligand-binding domain (LBD) of GluA2 and shows an IC50 of 13.4 nM for the GluA2 flop subtype. TDPAM01 can stabilize the activated conformation of GluA2 receptors, delay the receptor deactivation or desensitization process, maintaining the rapid excitatory synaptic transmission in the central nervous system[1].
Product Specifications
CAS Number
[2231103-08-3]
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=S1(=O)NCN(C2=CC(=CC=C21)CCC3=CC=C4C(=C3)N(C)CNS4(=O)=O)C
Molecular Formula
C18H22N4O4S2
Molecular Weight
422.52
References & Citations
[1]Laulumaa S, et al. Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. ACS Med Chem Lett. 2018 Nov 4;10 (3) :243-247.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Curated Selection
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