VUF14480
VUF14480 is a partial agonist of histamine H4 (hH4) receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 binds covalently to hH4 receptor (pKi: 6.3 for hH4-WT receptor) . VUF14480 partially induces hH4 receptor-mediated G protein activation and β-arrestin2 recruitment. VUF14480 can be used in the research of inflammatory diseases[1].
Product Specifications
CAS Number
1605304-31-1
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
N=1C(=NC(=CC1C=2C=CC=CC2)N3CCN(C)CC3)C=C
Molecular Formula
C17H20N4
Molecular Weight
280.38
References & Citations
[1]Nijmeijer S, et al. Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98 (3.36) of the human histamine H₄ receptor. Br J Pharmacol. 2013 Sep;170 (1) :89-100.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
bs-3452R-BF750 100 µL
Phospho-Rb (Thr821) Polyclonal Antibody, AbBy Fluor™ 750 Conjugated
Sign In for Pricing
View Details