CP-615003

CP-615003 is a potent and subtype-selective partial agonist of GABAA receptor (GABAA receptor) (Ki = 1.1 μM) . CP-615003 is mainly converted into the active metabolite CP-900725 through oxidative deamination in monkeys and humans, and the latter also has GABAA receptor affinity. CP-615003 is a substrate of P-glycoprotein (P-gp/MDR1), resulting in severe limitation of its penetration into the central nervous system (CNS) . CP-615003 can be used for the study of CNS-related indications[1].

Product Specifications

CAS Number

[329016-45-7]

Product Name Alternative

NGD-913

UNSPSC

12352005

Target

GABA Receptor

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1=CNC2=C1C(CCC2)=O)NC3=CC=C(C(F)=C3)OCCNCCC

Molecular Formula

C20H24FN3O3

Molecular Weight

373.42

References & Citations

[1]Venkatakrishnan K, et al. Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures. Drug metabolism and disposition. 2007 Aug 1;35 (8) :1341-9.