Indolidan
Indolidan (LY195115) is an orally active cardiotonic agent and a selective cyclic nucleotide phosphodiesterase inhibitor. Indolidan has a Ki of 80 nM for sarcoplasmic reticulum phosphodiesterase (SR-PDE) . Indolidan exhibits positive inotropic and vasodilator effects. Indolidan can be used in the research of diseases such as congestive heart failure[1][2].
Product Specifications
CAS Number
[100643-96-7]
Product Name Alternative
LY195115
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
CC1(C2=CC(C(CC3)=NNC3=O)=CC=C2NC1=O)C
Molecular Formula
C14H15N3O2
Molecular Weight
257.29
References & Citations
[1]Hayes JS, et al. Pharmacology of LY195115, a potent, orally active cardiotonic with a long duration of action. J Cardiovasc Pharmacol. 1987 Apr;9 (4) :425-34.|[2]Kauffman RF, et al. LY195115: a potent, selective inhibitor of cyclic nucleotide phosphodiesterase located in the sarcoplasmic reticulum. Mol Pharmacol. 1986 Dec;30 (6) :609-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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