NIR-BG2

NIR-BG2 is a near-infrared fluorescent probe targeting senescence-associated β-galactosidase (SA-β-Gal) . NIR-BG2 is activated by SA-β-Gal and undergoes hydrolysis to release electrophilic quinone methide that covalently binds to surrounding proteins for in situ labeling, with a 16-fold enhancement of fluorescence signal at 709 nm . NIR-BG2 is promising for research of vivo imaging of cellular senescence[1][2].

Product Specifications

CAS Number

[3036456-18-2]

UNSPSC

12352005

Target

Fluorescent Dye; Glycosidase

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Smiles

CCC[N+]1=C(/C=C/C2=C3C(CCC2)=CC4=CC(C(F)F)=C(OCC5=CC=C(C=C5)O[C@@H]6O[C@@H]([C@@H]([C@@H]([C@H]6O)O)O)CO)C=C4O3)C(C)(C)C7=CC=CC=C17

Molecular Formula

C42H46F2NO8+

Molecular Weight

730.81

References & Citations

[1]Liu J, et al. Noninvasive NIR Imaging of Senescence viaIn Situ Labeling. J Med Chem. 2021 Dec 23;64 (24) :17969-17978.|[2]Liu J, et al. A self-immobilizing NIR probe for non-invasive imaging of senescence[J]. BioRxiv, 2020: 2020.03. 27.010827.