DM-4111

DM-4111, one of the major monohydroxyl metabolites of Tolvaptan (HY-17000), is a potent vasopressin V2 receptor inhibitor. DM-4111 inhibits water reabsorption in the renal tubules, thereby promoting the excretion of electrolyte-free water. DM-4111 is promising for research of cardiovascular diseases[1][2].

Product Specifications

CAS Number

[926035-36-1]

UNSPSC

12352005

Target

Drug Metabolite; Vasopressin Receptor

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

O=C(NC1=CC=C(C(N2CC[C@H](O)[C@H](O)C3=CC(Cl)=CC=C32)=O)C(C)=C1)C4=CC=CC=C4C

Molecular Formula

C26H25ClN2O4

Molecular Weight

464.94

References & Citations

[1]Hoshikawa K, et al. Validated liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantitation of tolvaptan and its five major metabolites in human plasma. Ann Clin Biochem. 2019 May;56 (3) :387-396.|[2]Hoshikawa K, et al. Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients. Basic Clin Pharmacol Toxicol. 2020 Apr;126 (4) :353-363.