DM-4111
DM-4111, one of the major monohydroxyl metabolites of Tolvaptan , is a potent vasopressin V2 receptor inhibitor. DM-4111 inhibits water reabsorption in the renal tubules, thereby promoting the excretion of electrolyte-free water. DM-4111 is promising for research of cardiovascular diseases[1][2].
Product Specifications
CAS Number
926035-36-1
UNSPSC
12352005
Target
Drug Metabolite; Vasopressin Receptor
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C(NC1=CC=C(C(N2CC[C@H](O)[C@H](O)C3=CC(Cl)=CC=C32)=O)C(C)=C1)C4=CC=CC=C4C
Molecular Formula
C26H25ClN2O4
Molecular Weight
464.94
References & Citations
[1]Hoshikawa K, et al. Validated liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantitation of tolvaptan and its five major metabolites in human plasma. Ann Clin Biochem. 2019 May;56 (3) :387-396.|[2]Hoshikawa K, et al. Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients. Basic Clin Pharmacol Toxicol. 2020 Apr;126 (4) :353-363.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
V2 Receptor
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