Neltenexine
Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research[1][2].
Product Specifications
CAS Number
99453-84-6
UNSPSC
12352005
Target
CFTR; Elastase
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=CS1)NC2=C(C=C(C=C2Br)Br)CN[C@H]3CC[C@@H](CC3)O
Molecular Formula
C18H20Br2N2O2S
Molecular Weight
488.24
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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