Neltenexine

Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research[1][2].

Product Specifications

CAS Number

[99453-84-6]

UNSPSC

12352005

Target

CFTR; Elastase

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=CC=CS1)NC2=C(C=C(C=C2Br)Br)CN[C@H]3CC[C@@H](CC3)O

Molecular Formula

C18H20Br2N2O2S

Molecular Weight

488.24

References & Citations

[1]Braga PC, et al. Neltenexine: morphological investigation of protection against elastase-induced emphysema in rats. Drugs Exp Clin Res. 1995;21 (2) :51-7. |[2]Niisato N, et al. Action of neltenexine on anion secretion in human airway epithelia. Biochem Biophys Res Commun. 2007 May 18;356 (4) :1050-5.