Melafolone

Melafolone is a potent dual COX-2/EGFR inhibitor with IC50s of 13.2 μM (COX-2) and 17.4 μM (EGFR) . Melafolone enhances the effect of anti-PD-1 through vascular normalization and PD-L1 downregulation via the PI3K/Akt pathway in Lewis lung carcinoma (LLC) and CMT167 models. Melafolone can be used for lung cancer research[1].

Product Specifications

CAS Number

[129724-42-1]

UNSPSC

12352005

Target

Akt; COX; EGFR; PD-1/PD-L1; PI3K

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(C1=C(C(OC(C(C)CC)=O)=C(C(OC)=C1O)O)OC)/C=C/C2=CC=CC=C2

Molecular Formula

C22H24O7

Molecular Weight

400.42

References & Citations

[1]Tang H, et al. Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer. J Pharmacol Exp Ther. 2019 Mar;368 (3) :401-413.