Nafenodone
Nafenodone is an antidepressant agent. Nafenodone can reduce the rate and amplitude of contractions and lengthen sinus node recovery time. Nafenodone can inhibit the spontaneous mechanical activity in portal vein segmens with an IC50 of 1.4 μM in rat isolated vascular smooth muscle. Nafenodone relaxes the contractions induced by high K+ and noradrenaline[1][2].
Product Specifications
CAS Number
92615-20-8
UNSPSC
12352005
Target
Biochemical Assay Reagents
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C1C2=C(CCC1(CCN(C)C)C3=CC=CC=C3)C=CC=C2
Molecular Formula
C20H23NO
Molecular Weight
293.40
References & Citations
[1]Pérez-Vizcaino, F., et al., (1991) . Effects of (S) -nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres. European journal of pharmacology, 199 (1), 43-50. |[2]Pérez-Vizcaíno, F., et al., (1993) . Effects of (S) -nafenodone on 45Ca2+ fluxes and contractions in rat isolated vascular smooth muscle. European journal of pharmacology, 232 (1), 105-111.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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