Nafenodone

Nafenodone is an antidepressant agent. Nafenodone can reduce the rate and amplitude of contractions and lengthen sinus node recovery time. Nafenodone can inhibit the spontaneous mechanical activity in portal vein segmens with an IC50 of 1.4 μM in rat isolated vascular smooth muscle. Nafenodone relaxes the contractions induced by high K+ and noradrenaline[1][2].

Product Specifications

CAS Number

[92615-20-8]

UNSPSC

12352005

Target

Biochemical Assay Reagents

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C1C2=C(CCC1(CCN(C)C)C3=CC=CC=C3)C=CC=C2

Molecular Formula

C20H23NO

Molecular Weight

293.40

References & Citations

[1]Pérez-Vizcaino, F., et al., (1991) . Effects of (S) -nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres. European journal of pharmacology, 199 (1), 43-50. |[2]Pérez-Vizcaíno, F., et al., (1993) . Effects of (S) -nafenodone on 45Ca2+ fluxes and contractions in rat isolated vascular smooth muscle. European journal of pharmacology, 232 (1), 105-111.