TU-100
TU-100 is a Japanese herbal medicine. TU-100 exhibits anti-cancer effects by regulating cancer-associated fibroblasts (CAFs) in the TME. TU-100 can antagonize the M2 polarization phenotype of macrophages in the tumor microenvironment by suppressing the TLR4/NF-κB/STAT3 axis. TU-100 can inhibit the high expression of MMP-2, COX-2, and VEGF in TAMs[1].
Product Specifications
CAS Number
1310907-71-1
UNSPSC
12352005
Target
COX; MMP; NF-κB; STAT; Toll-like Receptor (TLR) ; VEGFR
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C1C2=C(C(C3=C1C4C(C5=C(C3N4C)C=CC=C5)=O)=O)C=CC=C2
Molecular Formula
C20H13NO3
Molecular Weight
315.32
References & Citations
[1]Chen S, et al. TU-100 Antagonizes the M2 Polarization Phenotype of Macrophages in the Tumor Microenvironment by Suppressing the TLR4/NF-B/STAT3 Axis. Anticancer Res. 2023 May;43 (5) :1985-1992.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2; MMP-2; STAT3; TLR4
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