CM-118

CM-118 is a potent and selective c-Met and ALK inhibitor. CM-118 inhibits the HGF-induced c-Met phosphorylation. CM-118 inhibits phosphorylation of ALK, EML4-ALKv1, ALK F1174L, and EMl4-ALKv1 L1196M, with respective IC50 values 0.92, 1.25, 1.9, and 3.5 μM. CM-118 exhibits anticancer activity against cancers dependent on the c-Met or ALK oncogenic pathways[1].

Product Specifications

CAS Number

[1370652-56-4]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; c-Met/HGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

C[C@H](C1=C(C(F)=CC=C1Cl)Cl)OC2=C(N)N=NC(C(NC3=CN(C(C=C3)=O)C)=O)=C2

Molecular Formula

C19H16Cl2FN5O3

Molecular Weight

452.27

References & Citations

[1]Meng L, et al. A novel lead compound CM-118: antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers. Cancer Biol Ther. 2014 Jun 1;15 (6) :721-34.