XEN-2174
XEN-2174 is a noradrenaline transporter (NET) inhibitor. XEN-2174 inhibits the reuptake of noradrenaline through non-competitive inhibition, increasing the concentration of noradrenaline in the synaptic cleft, thereby activating α2-adrenergic receptor at the spinal level and exerting analgesic effects. XEN-2174 exhibits long-lasting analgesic effects in models of neuropathic pain and postoperative pain in rats. XEN-2174 can be used in pain research[1].
Product Specifications
CAS Number
701909-57-1
UNSPSC
12352005
Target
Adrenergic Receptor; Monoamine Transporter
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C1N2[C@](C[C@H](C2)O)([H])C(N[C@@H](CSSC[C@@H](C(N[C@@]3([H])CSSC[C@@](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC3=O)=O)CC4=CC=C(C=C4)O)=O)CCCCN)=O)CC(C)C)=O)([H])C(N[C@H]1CC5=CN=CN5)=O)=O)NC([C@H](C(C)C)NC(CNC([C@@H]6CCC(N6)=O)=O)=O)=O)C(N)=O)=O
Molecular Formula
C58H85N17O16S4
Molecular Weight
1404.66
References & Citations
[1]Okkerse P, et al. Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties. Br J Clin Pharmacol. 2017 Apr;83 (4) :751-763.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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