N, N'-Bis (2,3-Dihydroxybenzoyl) -O-L-seryl-L-serine

N, N'-Bis (2,3-Dihydroxybenzoyl) -O-L-seryl-L-serine is a enterochelin hydrolyzed product. N, N'-Bis (2,3-Dihydroxybenzoyl) -O-L-seryl-L-serine can inhibit the invasion of murine colon cancer cells 26-L5 with an IC50 of 2.7 μM, and has anti-tumor effect. In addition, N, N'-Bis (2,3-Dihydroxybenzoyl) -O-L-seryl-L-serine has no appreciable antimicrobial activities against Micrococcus luteus, Escherichia coli and Candida albicans[1][2].

Product Specifications

CAS Number

[30414-15-4]

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(C1=C(C(O)=CC=C1)O)N[C@H](C(O)=O)COC([C@H](CO)NC(C2=C(C(O)=CC=C2)O)=O)=O

Molecular Formula

C20H20N2O11

Molecular Weight

464.38

References & Citations

[1]Igarashi Y, et al. Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp. J Antibiot (Tokyo) . 2012 Apr;65 (4) :207-9. |[2]O'Brien IG, et al. Enterochelin hydrolysis and iron metabolism in Escherichia coli. Biochim Biophys Acta. 1971 Jun 22;237 (3) :537-49.