S-N6-Methyladenosylhomocysteine
S-N6-Methyladenosylhomocysteine (Chart 1-1) is a potent inhibitor of histone methyltransferase DOT1L, with the IC50 of 0.29 μM. S-N6-Methyladenosylhomocysteine plays an important role in cancer research[1].
Product Specifications
CAS Number
[53228-06-1]
UNSPSC
12352005
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O[C@@H]1[C@H](O)[C@@H](CSCC[C@H](N)C(O)=O)O[C@H]1N(C=N2)C3=C2C(NC)=NC=N3
Molecular Formula
C15H22N6O5S
Molecular Weight
398.44
References & Citations
[1]Baylor College of Medicine. Selective inhibitors of histone methyltransferase DOT1L. United States, US20140100184 A1 2014-04-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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