PIN1 degrader-1
PIN1 degrader-1 (Compound 158H9) is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 21.5 nM. PIN1 degrader-1 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation. PIN1 degrader-1 inhibits the cell viability of multi cancer cells, and can be used in cancer research[1].
Product Specifications
CAS Number
3080918-50-6
UNSPSC
12352005
Target
PIN1
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@H]3CCCCN3C([C@H](CC4=CNC5=C4C=CC(Cl)=C5)NC(CCl)=O)=O)=O)=O
Molecular Formula
C30H32Cl2N6O4
Molecular Weight
611.52
References & Citations
[1]Alboreggia G, et al., Targeted degradation of Pin1 by protein-destabilizing compounds. Proc Natl Acad Sci U S A. 2024 Nov 19;121 (47) :e2403330121.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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