PIN1 degrader-1

PIN1 degrader-1 (Compound 158H9) is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 21.5 nM. PIN1 degrader-1 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation. PIN1 degrader-1 inhibits the cell viability of multi cancer cells, and can be used in cancer research[1].

Product Specifications

CAS Number

[3080918-50-6]

UNSPSC

12352005

Target

PIN1

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@H]3CCCCN3C([C@H](CC4=CNC5=C4C=CC(Cl)=C5)NC(CCl)=O)=O)=O)=O

Molecular Formula

C30H32Cl2N6O4

Molecular Weight

611.52

References & Citations

[1]Alboreggia G, et al., Targeted degradation of Pin1 by protein-destabilizing compounds. Proc Natl Acad Sci U S A. 2024 Nov 19;121 (47) :e2403330121.