FXR agonist 12
FXR agonist 12 (Compound C7) is the orally active agonist for FXR. FXR agonist 12 down-regulates bile acid synthesis-related genes, and up-regulates bile acid transport-related genes in HepG2 cells. FXR agonist 12 improves ANIT-induced cholestasis, ameliorates the liver damage and fibrosis in mouse NASH models[1].
Product Specifications
CAS Number
1831862-88-4
UNSPSC
12352211
Target
FXR
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
C[C@@]12[C@]3([H])[C@]([C@@H]([C@@H]([C@]1([H])CCCC2)CC)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(O)=O)C
Molecular Formula
C26H44O3
Molecular Weight
404.63
References & Citations
[1]Yang J, et al., Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch. Cell. 2024 Dec 12;187 (25) :7164-7182.e18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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