FXR agonist 12

FXR agonist 12 (Compound C7) is the orally active agonist for FXR. FXR agonist 12 down-regulates bile acid synthesis-related genes, and up-regulates bile acid transport-related genes in HepG2 cells. FXR agonist 12 improves ANIT-induced cholestasis, ameliorates the liver damage and fibrosis in mouse NASH models[1].

Product Specifications

CAS Number

[1831862-88-4]

UNSPSC

12352211

Target

FXR

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

C[C@@]12[C@]3([H])[C@]([C@@H]([C@@H]([C@]1([H])CCCC2)CC)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(O)=O)C

Molecular Formula

C26H44O3

Molecular Weight

404.63

References & Citations

[1]Yang J, et al., Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch. Cell. 2024 Dec 12;187 (25) :7164-7182.e18.