Lumateperone metabolite 1

Lumateperone metabolite 1 (Formula T) is a metabolite of Lumateperone (HY-17637) [1]. Lumateperone (ITI-007) is an orally active 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator[2][3]

Product Specifications

CAS Number

[1469777-40-9]

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; Drug Metabolite

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

OC(C1=CC=C(C=C1)F)CCCN2C[C@@]3([H])C4=CC=CC5=C4N(CCN5)[C@@]3([H])CC2

Molecular Formula

C23H28FN3O

Molecular Weight

381.49

References & Citations

[1]Sharon Mates, et al. Organic compounds. WO2015154025A1.|[2]Jinyuan Zhang, et al. Identification of Trovafloxacin, Ozanimod, and Ozenoxacin as Potent c-Myc G-quadruplex Stabilizers to Suppress c-Myc Transcription and Myeloma Growth. Mol Inform. 2022 Mar 30:e2200011. |[3]J Titulaer, et al. Lumateperone-mediated effects on prefrontal glutamatergic receptor-mediated neurotransmission: A dopamine D1 receptor dependent mechanism. Eur Neuropsychopharmacol. 2022 Jul 22;62:22-35.