CP-470711
CP-470711 is an orally active and potent and selective sorbitol dehydrogenase (SDH) inhibitor with an IC50=10 nM for human SDH and IC50=17 nM for rat SDH. CP-470711 is promising for research of chronic complications related to type 2 diabetes mellitus, such as neuropathy and nephropathy[1].
Product Specifications
CAS Number
300548-99-6
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease; Neurological Disease
Smiles
C[C@@H]1N(C2=NC([C@H](O)C)=NC=C2)[C@@H](CN(C3=NC([C@H](O)C)=NC=C3)C1)C
Molecular Formula
C18H26N6O2
Molecular Weight
358.44
References & Citations
[1]Chu-Moyer MY, et al. SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711. Bioorg Med Chem Lett. 2002 Jun 3;12 (11) :1477-80.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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