CP-470711

CP-470711 is an orally active and potent and selective sorbitol dehydrogenase (SDH) inhibitor with an IC50=10 nM for human SDH and IC50=17 nM for rat SDH. CP-470711 is promising for research of chronic complications related to type 2 diabetes mellitus, such as neuropathy and nephropathy[1].

Product Specifications

CAS Number

[300548-99-6]

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Neurological Disease

Smiles

C[C@@H]1N(C2=NC([C@H](O)C)=NC=C2)[C@@H](CN(C3=NC([C@H](O)C)=NC=C3)C1)C

Molecular Formula

C18H26N6O2

Molecular Weight

358.44

References & Citations

[1]Chu-Moyer MY, et al. SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711. Bioorg Med Chem Lett. 2002 Jun 3;12 (11) :1477-80.