NSC 641396

NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. NSC 641396 is also a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. NSC 641396 has antitumor activity[1][2].

Product Specifications

CAS Number

[605685-94-7]

UNSPSC

12352005

Target

DNA/RNA Synthesis; Histone Methyltransferase

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C1C=CC(C2=C1C=CC3=C2N(C)C4=CC=C(OC)C=C34)=O

Molecular Formula

C18H13NO3

Molecular Weight

291.30

References & Citations

[1] Tholander F, et al. Discovery of antimicrobial ribonucleotide reductase inhibitors by screening in microwell format. Proc Natl Acad Sci U S A. 2012 Jun 19;109 (25) :9798-803.|[2]Dong H, et al. Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nat Cancer. 2024 Apr;5 (4) :601-624.