NSC 641396
NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. NSC 641396 is also a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. NSC 641396 has antitumor activity[1][2].
Product Specifications
CAS Number
605685-94-7
UNSPSC
12352005
Target
DNA/RNA Synthesis; Histone Methyltransferase
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C1C=CC(C2=C1C=CC3=C2N(C)C4=CC=C(OC)C=C34)=O
Molecular Formula
C18H13NO3
Molecular Weight
291.30
References & Citations
[1] Tholander F, et al. Discovery of antimicrobial ribonucleotide reductase inhibitors by screening in microwell format. Proc Natl Acad Sci U S A. 2012 Jun 19;109 (25) :9798-803.|[2]Dong H, et al. Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nat Cancer. 2024 Apr;5 (4) :601-624.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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