SB1578

SB1578 (CT-1578) is a selective JAK2 and FLT3 inhibitor with an IC50 of 46 nM and 60 nM, respectively. SB1578 exhibits high selectivity for other kinase targets. SB1578 can be used for the study of non-oncology indication rheumatoid arthritis[1].

Product Specifications

CAS Number

[937273-04-6]

Product Name Alternative

CT-1578

UNSPSC

12352005

Target

FLT3; JAK

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

N1(CCCC1)CCOC2=CC=C3C=C2COC/C=C/COCC4=CC=C(O4)C5=CC=N/C(N5)=N/3

Molecular Formula

C26H30N4O4

Molecular Weight

462.54

References & Citations

[1]Poulsen A, et al. Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3) . J Comput Aided Mol Des. 2012 Apr;26 (4) :437-50.