KRAS inhibitor-27
KRAS inhibitor-27 (Compound 15h) is the inhibitor for KRAS. KRAS inhibitor-27 inhibits KRAS G12D/G12V mutated cells AsPC-1, SW620 and KRAS wildtype cell HT-29 with IC50 of 378, 0.6 and 3230 nM, respectively. KRAS inhibitor-27 inhibits ERK phosphorylation (IC50 in cell AsPC-1 and SW620 is 0.6 nM and 1 nM), reduces the expression of DUSP4, thereby inhibiting MAPK signaling pathway[1].
Product Specifications
CAS Number
3033690-83-1
UNSPSC
12352005
Target
ERK; p38 MAPK; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer
Smiles
F[C@@H]1C[C@]2(COC3=NC4=C5C(OC[C@@]6(COCCCN64)[H])=C(Cl)[C@]([C@](C=CC(F)=C7S8)=C7C(C#N)=C8N)=C(F)C5=N3)CCCN2C1
Molecular Formula
C31H28ClF3N6O3S
Molecular Weight
657.11
References & Citations
[1]Hong C, et al. Discovery of novel tetracyclic quinazolines as multi-KRASáinhibitors for the treatment of solid tumors[J]. Bioorganic & Medicinal Chemistry Letters, 2025, 118: 130087.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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