KRAS inhibitor-27

KRAS inhibitor-27 (Compound 15h) is the inhibitor for KRAS. KRAS inhibitor-27 inhibits KRAS G12D/G12V mutated cells AsPC-1, SW620 and KRAS wildtype cell HT-29 with IC50 of 378, 0.6 and 3230 nM, respectively. KRAS inhibitor-27 inhibits ERK phosphorylation (IC50 in cell AsPC-1 and SW620 is 0.6 nM and 1 nM), reduces the expression of DUSP4, thereby inhibiting MAPK signaling pathway[1].

Product Specifications

CAS Number

[3033690-83-1]

UNSPSC

12352005

Target

ERK; p38 MAPK; Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Field of Research

Cancer

Smiles

F[C@@H]1C[C@]2(COC3=NC4=C5C(OC[C@@]6(COCCCN64)[H])=C(Cl)[C@]([C@](C=CC(F)=C7S8)=C7C(C#N)=C8N)=C(F)C5=N3)CCCN2C1

Molecular Formula

C31H28ClF3N6O3S

Molecular Weight

657.11

References & Citations

[1]Hong C, et al. Discovery of novel tetracyclic quinazolines as multi-KRASáinhibitors for the treatment of solid tumors[J]. Bioorganic & Medicinal Chemistry Letters, 2025, 118: 130087.