Cardiomyocyte proliferation promoting agent-1
Cardiomyocyte proliferation promoting agent-1 ((E/Z) -GA-002), the E/Z mixture compound, is a cardiomyocyte proliferation promoting agent. GA-002 (single E configuration) is a LATS1 and LATS2 kinase inhibitor with IC50 values of 3.93 nM and 3.87 nM, respectively. GA-002 induces Hippo pathway-regulated gene, inhibits YAP/TAZ phosphorylation, and induces YAP nuclear translocation[1].
Product Specifications
CAS Number
2351906-71-1
Product Name Alternative
(E/Z) -GA-002
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Cardiovascular Disease
Purity
99.87
Smiles
O=C(C(C)NC1=CC=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O
Molecular Formula
C19H23N3O3
Molecular Weight
341.40
References & Citations
[1]Cardiomyocyte growth promoter. JP2023007595A 2023-01-19.|[2]Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298 (4) :101779.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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