Cardiomyocyte proliferation promoting agent-1

Cardiomyocyte proliferation promoting agent-1 ((E/Z) -GA-002), the E/Z mixture compound, is a cardiomyocyte proliferation promoting agent. GA-002 (single E configuration) is a LATS1 and LATS2 kinase inhibitor with IC50 values of 3.93 nM and 3.87 nM, respectively. GA-002 induces Hippo pathway-regulated gene, inhibits YAP/TAZ phosphorylation, and induces YAP nuclear translocation[1].

Product Specifications

CAS Number

[2351906-71-1]

Product Name Alternative

(E/Z) -GA-002

UNSPSC

12352005

Target

YAP

Related Pathways

Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Cardiovascular Disease

Purity

99.87

Smiles

O=C(C(C)NC1=CC=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O

Molecular Formula

C19H23N3O3

Molecular Weight

341.40

References & Citations

[1]Cardiomyocyte growth promoter. JP2023007595A 2023-01-19.|[2]Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298 (4) :101779.